Activated disinfectant hydrogen peroxide compositions

ABSTRACT

Activated hydrogen peroxide disinfecting compositions are provided especially for low-foaming applications. A concentrate for dilution by an end-user is provided, which includes a hydrogen peroxide source, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, and an optional organic acid. Also provided is a ready-to-use hydrogen peroxide, disinfectant solution including a biocidal amount of hydrogen peroxide, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, water as solvent and an optional organic acid. An end-user can disinfect a surface of microorganisms by contacting the surface with the disinfecting composition for an amount of time effective to kill a majority of the microbes located on the surface.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority under 35 U.S.C. §119(e) fromProvisional Application No. 62/051,575, filed Sep. 17, 2014, thedisclosure of which is incorporated herein by reference.

FIELD OF THE INVENTION

The present invention relates to hydrogen peroxide disinfectants in bothconcentrate and ready-to-use forms, and more particularly to activatedhydrogen peroxide solutions with improved disinfectant and antimicrobialproperties.

BACKGROUND OF THE INVENTION

Over the years, efforts have been focused on developing highly activeantimicrobial compositions effective against a broad spectrum ofmicroorganisms. However, these compositions also need to have lowtoxicity against humans and animals and be safe to the environment.

Among the known disinfectants and antimicrobials, hydrogen peroxide is apreferred choice not only due to its potential as a biocide but also dueto its low toxicity because it decomposes to give nontoxic oxygen andwater. Unfortunately, hydrogen peroxide is not very efficient by itselfwith its low kill rate against certain organisms although it shows abroad spectrum of biocidal activities and is widely used.

An example of the low kill rate for hydrogen peroxide is that a 6 weightpercent (“wt. %”) hydrogen peroxide solution, within a 5 minutes contacttime, will only exhibit approximately a 3 Log (i.e., 1000-fold)reduction against Staphylococcus Aureus, and less than a 2 Log(100-fold) reduction against Pseudomonas Aeruginosa. Likewise, a 6000ppm (i.e., 0.6 wt. %) hydrogen peroxide solution, within a 5 minutecontact time, will only exhibit about a 1 log reduction againstStaphylococcus Aureus, and less than a 1 Log reduction againstPseudomonas Aeruginosa.

The killing efficiency of hydrogen peroxide can be improved by usinghighly concentrated hydrogen peroxide or a longer contact time. However,hydrogen peroxide at a concentration higher than 7.5 wt. % is corrosive.As a result, special handling procedures are required for suchconcentrations. Additionally, contact times longer than 5 minutes aregenerally not acceptable for most disinfectant applications.

Because of these difficulties in increasing kill rates, efforts havebeen made on developing activated hydrogen peroxide formulations toimprove the efficacy and killing rate of hydrogen peroxide withouthaving to resort to high hydrogen peroxide concentrations and contacttimes greater than 5 minutes. The development of these activatedhydrogen peroxide formulations is especially important to industriessuch as the food, health-care, hospitality, and even household use.

One attempt to enhance the efficacy of hydrogen peroxide disinfectingsolutions is found in U.S. Pat. No. 5,523,012 to Winterton et al.(“Wintertown”). Wintertown discloses that the addition of anionicsulfosuccinate surfactants to an aqueous, hydrogen peroxide solutionimproved the killing time against Aspergillus fumigatus to 7.1 minutes.However, the improvement in killing time is still far too long for mostdisinfectant applications.

Another attempt to enhance the efficacy of hydrogen peroxidedisinfecting solutions is found in U.S. Pat. No. 5,264,229 to Mannig etal. (“Mannig”). Mannig discloses a process for reducing the overallbacterial count and increasing the shelf life of the aqueous hydrogenperoxide solution by adding sulfo-based surfactants, such as, alkylarylsulfonates, sulfates, sulfonates of oils and fatty acid, sulfate ofalcohols and sulfosuccinates.

In U.S. Pat. No. 7,658,953, a biocidal hydrogen peroxide composition isenhanced by the addition of a surfactant with a structure:R—O—(CH(Y)—CH₂—O)_(n)—CH₂—COOH, wherein R is C₆ to C₁₂ alkyl, Y is H orCH₃, and n is 3-10. The addition of the surfactant was reported toachieve a Log 6 reduction of bacteria in a bacteria suspension within 1min upon contact with the composition.

Several other patents and patent publications disclose the addition ofanionic surfactants based on sulfonic acid to increase the kill rate ofan aqueous hydrogen peroxide disinfecting solution: U.S. Pat. No.7,354,604, U.S. Publication Nos.: 2010/0330196, 2011/0262557,2011/0129435, 2011/0182958, 2012/0230869, 2012/0177746, 2012/0164237,and European Publication No.: 2338343. The anionic surfactant is chosenfrom C₈ to C₁₆ alkyl aryl sulfonic acids, sulfonated C₁₂ to C₂₂carboxylic acids, C₆ to C₂₂ alkyl diphenyl oxide sulfonic acids, C₈ toC₂₂ alkyl sulfonic acids, and C₆ to C₁₈ alkyl or alkenyl esters ofsulfosuccinic acids.

However, the use of anionic sulfonic acid-based surfactants is lessdesired in low foaming applications where disinfection, and notcleaning, is the primary function to be achieved.

In view of these strategies for increasing the kill rate of the aqueoushydrogen peroxide disinfecting solutions, there is still a need for moreefficacious biocidal compositions that provide shorter contact times(i.e., faster rates of kill, e.g. 5 minutes or less) without an anionicsurfactant. There is also a need aqueous hydrogen peroxide disinfectingsolutions with a broader spectrum of activity especially againstproblematic biocidal targets such as Staphylococcus aureus, andPseudomonas aeruginosa.

SUMMARY OF THE INVENTION

It has now been found that the biocidal activity of aqueous hydrogenperoxide solutions can be surprisingly enhanced with the addition of anon-surfactant sulfonic acid or salt thereof, and optionally anadditional acid other than the sulfonic acid. One advantage of thepresent invention is that anionic sulfonic acid-based, surfactants canbe avoided. Another advantage is that mineral acids can avoided is sodesired. In one embodiment, the present invention provides a hydrogenperoxide, disinfectant concentrate that includes a hydrogen peroxidesource, a non-surfactant organic sulfonic acid or salt thereof, anon-ionic surfactant, and an optional acid other than the sulfonic aciddescribed above. In another embodiment, the present invention provides aready-to-use hydrogen peroxide, disinfectant solution that includes abiocidal amount of hydrogen peroxide, a non-surfactant organic sulfonicacid or salt thereof, a non-ionic surfactant, water as solvent and anoptional acid other than the sulfonic acid. In still another embodiment,the present invention provides a method of disinfecting a surface ofmicroorganisms by contacting the surface with the disinfectingcomposition for an amount of time effective to kill a majority of themicrobes located on the surface.

As described above, the present invention in one embodiment provides ahydrogen peroxide, disinfectant concentrate including a hydrogenperoxide source, a non-surfactant organic sulfonic acid or salt thereof,and a non-ionic surfactant. The concentrate is typically a solidformulation in the form of a powder or tablet.

The hydrogen peroxide source is typically about 2 to about 8 weightpercent of the total concentrate. Examples of the hydrogen peroxidesources include hydrogen peroxide solution, sodium percarbonate,potassium percarbonate, sodium and potassium perborate, hydrogenperoxide urea, hydrated forms thereof, and mixtures thereof.

Examples of non-surfactant organic sulfonic acids or their salts includea C₁-C₇ alkylsulfonic acid, a sulfonated C₁-C₇ carboxylic acid, asubstituted or unsubstituted aromatic sulfonic acid,mono-alkylphenylsulfonic acid, a di-alkylphenylsulfonic acid, where thesubstituted aromatic sulfonic acid is substituted with at least oneC₁-C₃ alkyl group, and mixtures thereof. In another embodiment, thealkylsulfonic acid and the sulfonated carboxylic acid will have a C₁-C₅alkyl group. An example of the C₁-C₇ alkylsulfonic acid includesmethanesulfonic acid. An example of the unsubstituted aromatic sulfonicacid includes benzene sulfonic acid. Examples of substituted aromaticsulfonic acids include toluene sulfonic acid, xylenesulfonic acid,ethylbenzene sulfonic acid and mixtures thereof. Examples of salt formsinclude alkali metal salts, alkaline earth metal salts and ammoniumsalts. The non-surfactant organic sulfonic acid is typically about 2 toabout 15 weight percent of the total concentrate.

In another embodiment of the hydrogen peroxide, disinfectantconcentrate, the concentrate can further include an optional acid otherthan the non-surfactant organic sulfonic acid. The optional acid can bephosphoric acid, etidronic acid, and mixtures thereof. The optional acidcan also be a carboxylic acid such as a C₁ to C₈ mono-, di-, ortricarboxylic acid, a C₁ to C₈ hydroxyl carboxylic acid, a substitutedor unsubstituted aromatic carboxylic acid, and mixtures thereof. In yetanother embodiment, the optional acid can be a mineral acid. Theoptional acid is typically about 0.2 to about 10 weight percent of thetotal concentrate.

Examples of the nonionic surfactant include a C₈ to C₁₄ alkylatedpolyethylene glycol, C₈ to C₁₄ alkylated polypropylene glycol,polyoxyethylene glycol alkylphenol ethers and glucoside alkyl ethers, ormixtures thereof. The nonionic surfactant is typically about 0.5 toabout 8 weight percent of the total concentrate.

In yet another embodiment of the concentrate, the concentrate canfurther include a hydrogen peroxide stabilizer and a metal corrosioninhibitor. Both the hydrogen peroxide stabilizer and a metal corrosioninhibitor are typically about 0.05 to about 0.5 weight percent of thetotal concentrate. The concentrate can further include a biocidalquaternary ammonium salt in an amount from about 0.1 to about 10 weightpercent of the total concentrate. In another embodiment, the concentratecan further include a zwitterionic surfactant, an ionic surfactant orboth. The zwitterionic surfactant and the ionic surfactant, if present,are typically about 0.5 to about 5 weight percent of the concentrate.

As further described above, the present invention in another embodimentprovides a ready-to-use hydrogen peroxide, disinfectant solutionincluding a biocidal amount of hydrogen peroxide, a non-surfactantorganic sulfonic acid or salt thereof, a non-ionic surfactant, andwater. It will be apparent to one skilled in the art that the sameabove-described components for the concentrate can be the samecomponents for the hydrogen peroxide, the non-surfactant organicsulfonic acid or salt thereof, and the non-ionic surfactant of theready-to-use solution. For example, just like the concentrate, thenon-surfactant organic sulfonic acid of the ready-to-use solutionincludes a C₁-C₇ or C₁-C₅ alkylsulfonic acid, a sulfonated C₁-C₇ orC₁-C₅ carboxylic acid, a substituted or unsubstituted aromatic sulfonicacid, mono-alkylphenylsulfonic acid, a di-alkylphenylsulfonic acid,where the substituted aromatic sulfonic acid is substituted with atleast one C₁-C₃ alkyl group and mixtures thereof. An example of theC₁-C₇ or C₁-C₅ alkylsulfonic acid includes methanesulfonic acid. Anexample of the unsubstituted aromatic sulfonic acid includes benzenesulfonic acid. Examples of the substituted aromatic sulfonic acidinclude toluene sulfonic acid, xylenesulfonic acid, ethylbenzenesulfonic acid and mixtures thereof. Examples of salts include alkalimetal salts, alkaline earth metal salts and ammonium salts.

The biocidal amount of hydrogen peroxide in the ready-to-use solution istypically from about 0.05 to about 5.0 weight percent of the totalsolution. The non-surfactant organic sulfonic acid in the ready-to-usesolution is typically about 0.05 to about 5.0 weight percent of thetotal solution. The nonionic surfactant is in the ready-to-use solutionis typically about 0.05 to about 3.0 weight percent of the totalsolution.

In another embodiment, the ready-to-use solution can further include anoptional acid such as a carboxylic acid or a mineral acid (i.e., aninorganic acid). The amount of the carboxylic acid or a mineral acid istypically from about 0.05 to about 6.0 weight percent of the totalsolution. The solution can have a pH of from about 1.0 to about 4.0. Theready-to-use solution can further include a biocidal quaternary ammoniumsalt in an amount from about 0.1 to about 5 weight percent of thesolution. In another embodiment, the ready-to-use solution can furtherinclude a zwitterionic surfactant, an ionic surfactant or both. Thezwitterionic surfactant and the ionic surfactant, if present, aretypically about 0.5 to about 5 weight percent of the concentrate.

In addition to water, the ready-to-use solution can further include awater-miscible organic solvent. Examples of water-miscible solventsinclude ethanol, propanol, benzyl alcohol, phenoxyethanol, isopropanol,diethylene glycol propyl ether, ethylene glycol monomethyl ether,ethylene glycol monoethyl ether, ethylene glycol monopropyl ether,ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether,diethylene glycol monomethyl ether, diethylene glycol monobutyl ether,diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether,ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethyleneglycol dibutyl ether, propylene glycol n-butyl ether, tripropyleneglycol methyl ether, dipropylene glycol methyl ether, dipropylene glycolbutyl ether and combinations thereof.

In yet another embodiment, the present invention provides a method ofdisinfecting a surface of microorganisms with the ready-to-use solutionof the invention. The method includes the step of contacting the surfacewith a disinfecting composition including (i) a biocidal amount ofhydrogen peroxide, (ii) a non-surfactant organic sulfonic acid or saltthereof, (iii) a non-ionic surfactant, and (iv) water, where the surfaceis contacted for an amount of time effective to kill a majority of themicrobes located on the surface. Examples of microorganisms to be killedinclude Gram positive bacteria, Gram negative bacteria, viruses, fungi,mildew, mold and combinations thereof. More specific examples ofmicroorganisms to be killed include Staphylococcus, Pseudomonas,hepatitis, rotavirus, rhinovirus, tuberculosis and combinations thereof.Examples of surfaces to be disinfected with the ready-to-use solutioninclude floors, walls, countertops, appliances, and fixtures.

In one more embodiment, the present invention provides a two-partdisinfectant. The two-part disinfectant has a first container includinga non-surfactant organic sulfonic acid or salt thereof, and a non-ionicsurfactant, and a second container including a biocidal amount ofhydrogen peroxide, and water. In a further embodiment, the additionalcomponents are included only in the first container.

These and other unique aspects of the present invention will become morereadily apparent from the detailed description set forth below.

DETAILED DESCRIPTION OF THE INVENTION

The present invention advantageously provides a hydrogen peroxidedisinfectant concentrate, and a ready-to-use hydrogen peroxidedisinfectant solution. Further, the present invention provides a methodof using the solution to disinfect substrates from troublesomemicroorganisms such as Staphylococcus aureus, and Pseudomonasaeruginosa. One unique aspect of the present invention, as compared tothe prior art, is that inventive compositions and methods avoid the useof sulfonate-based anionic surfactants typically found in activatedhydrogen peroxide formulations. The omission of anionic sulfonicacid-based, surfactants allows the solutions to be used in applicationswere low foaming is desired or is advantageous.

In accordance with the invention, both the concentrate and theready-to-use solution include (i) a hydrogen peroxide source, (ii) anon-surfactant organic sulfonic acid or salt thereof, (iii) a non-ionicsurfactant, and (iv) an optional additional acid other than the organicsulfonic acid. The ready-to-use solution also includes an aqueoussolvent such as water and/or water-miscible organic solvents.Water-miscible organic solvents to be used include: alcoholic solventssuch as ethanol, propanol, benzyl alcohol, phenoxyethanol, andisopropanol; and alkyl and dialkly glycol ethers of ethylene glycol orpropylene glycol, such as diethylene glycol propyl ether, ethyleneglycol monomethyl ether, ethylene glycol monoethyl ether, ethyleneglycol monopropyl ether, ethylene glycol monoisopropyl ether, ethyleneglycol monobutyl ether, diethylene glycol monomethyl ether, diethyleneglycol monobutyl ether, diethylene glycol monoethyl ether, diethyleneglycol mono-n-butyl ether, ethylene glycol dimethyl ether, ethyleneglycol diethyl ether, ethylene glycol dibutyl ether, propylene glycoln-butyl ether, tripropylene glycol methyl ether, dipropylene glycolmethyl ether, and dipropylene glycol butyl ether. When thewater-miscible organic solvent is used with water, it can be diluted ina range with water from about 0.5% to about 20% by weight of waterpresent in the ready-to-use solution. In another embodiment,water-miscible organic solvent is diluted from about 1% to about 5% byweight of water present in the ready-to-use solution.

Hydrogen peroxide sources to be used in the invention include, but arenot limited to, aqueous hydrogen peroxide solution, sodium percarbonate,potassium percarbonate, sodium and potassium perborate, hydrogenperoxide urea, as well as their hydrated forms, and mixtures thereof. Inone embodiment, the hydrogen peroxide source is an aqueous solutioncontaining about 20 to about 50% by weight hydrogen peroxide dissolvedin water. In another embodiment, the hydrogen peroxide source is a solidformulation of sodium percarbonate.

As will be apparent to those skilled in the art, the amount of hydrogenperoxide is variable depending on whether the composition is aconcentrate or a ready-to-use solution. The amount of the hydrogenperoxide source in the concentrate is from about 1.0 to about 8.0 weightpercent (“w/w %”) of the total formulation depending on storagestability. As noted above, concentrations above 7.5 w/w % are generallyconsidered corrosive and unstable to many applications. Typically, theconcentrate contains from 2 to 7 w/w % of the hydrogen peroxide source.In contrast, the amount of hydrogen peroxide source in the ready-to-usesolution is a biocidal amount that can range from about 0.05 to about5.0 w/w % of the total solution depending on application. In anotherembodiment, the biocidal amount ranges from about 0.05 to about 2.0 w/w%. Typically, the ready-to-use solution contains from 0.1 to 1.5 w/w %of the hydrogen peroxide source.

Non-surfactant organic sulfonic acids to be used in the inventioninclude, but are not limited to, a C₁-C₇ alkylsulfonic acid, asulfonated C₁-C₇ carboxylic acid, a substituted or unsubstitutedaromatic sulfonic acid, mixtures thereof and salts thereof. In anotherembodiment, the alkylsulfonic acid and sulfonated carboxylic acid have aC₁-C₅ chain. In the case of a substituted aromatic sulfonic acid, thearomatic ring is substituted with at least one C₁-C₃ alkyl group. Statedotherwise, if the aromatic ring is substituted the alkyl group shouldcontain three (3) carbons or less. Salts of the non-surfactant organicsulfonic acid are alkali metal and alkaline earth metals salts, such assodium, potassium, calcium and magnesium. Salts may also includeammonium salts. Representative examples of the non-surfactant organicsulfonic acid are methane sulfonic acid, benzene sulfonic acid, toluenesulfonic acid, xylenesulfonic acid, ethylbenzene sulfonic acid, andmixtures thereof. The amount of the non-surfactant organic sulfonic acidin concentrate is from about 1 to about 20 w/w % of the totalformulation. Typically, the concentrate contains from 3 to 15 w/w % ofthe non-surfactant organic sulfonic acid. The amount of thenon-surfactant organic sulfonic acid in the ready-to-use solution isfrom about 0.05 (e.g., 0.1) to about 5 w/w % of the total solution.Typically, the ready-to-use solution contains from about 0.5 to about 3w/w % of the non-surfactant organic sulfonic acid.

The non-ionic surfactants to be used in the invention include, but arenot limited to, polyoxyethylene glycol alkyl ethers, octaethylene glycolmonododecyl ether, pentaethylene glycol monododecyl ether,polyoxypropylene glycol alkyl ethers, glucoside alkyl ethers, decylglucoside, lauryl glucoside, octyl glucoside, polyoxyethylene glycoloctylphenol ethers, polyoxyethylene glycol alkylphenol ethers, glycerolalkyl esters, polyglycerol esters, glyceryl laurate, polyoxyethyleneglycol sorbitan alkyl esters, sorbitan alkyl esters,dodecyldimethylamine oxide, block copolymers of polyethylene glycol andpolypropylene glycol, poloxamers and polyethoxylated tallow amine(POEA), and mixtures thereof. The amount of the nonionic surfactant inthe concentrate is from about 1 to about 8% w/w % of the formulation.Typically, the concentrate contains from 2 to 5 w/w % of nonionicsurfactant. The amount of the nonionic surfactant in the ready-to-usesolution is from about 0.05 to about 3 w/w % of the solution. In anotherembodiment, the nonionic surfactant in the ready-to-use solution is fromabout 0.05 to about 1.5 w/w % of the solution. Typically, theready-to-use solution contains from 0.06 to 1 w/w % of the nonionicsurfactant.

In accordance to the present invention, there may be an optional acidadded to the composition other than the non-surfactant organic sulfonicacid, and in addition to the non-surfactant organic sulfonic acid. Theoptional acid may be a carboxylic acid or a mineral acid (i.e., aninorganic acid). The optional acid may be added up to an amount of about10 w/w %.

The optional carboxylic acid which may be used in the present invention,excludes the non-surfactant organic sulfonic acids described herein andincludes, but are not limited to, a C₁ to C₈ mono, di- or tricarboxylicacid, a C₁ to C₈ hydroxyl carboxylic acid, a substituted orunsubstituted aromatic carboxylic acid. In the case of a substitutedaromatic carboxylic acid, the aromatic ring is substituted with at leastone alkyl group having three (3) or less carbons. Representativeexamples of carboxylic acids to be used include, but are not limited to,acetic acid, propionic acid, butyric acid, pentanoic acid, hexanoicacid, octanoic acid, succinic acid, citric acid, oxalic acid, tartaricacid, glutaric acid, adipic acid, benzoic acid, phthalic acid, andmixtures thereof. In one embodiment, the carboxylic acid is acetic acid,octanoic acid, hexanoic acid, succinic acid, citric acid, glutaric acid,adipic acid, and mixtures thereof. The amount of carboxylic acid in theconcentrate is from about 0.5 to about 8 w/w % of the formulation.Typically, the concentrate contains from 1 to 5 w/w % of the carboxylicacid, which is dependent on storage stability. The amount of carboxylicacid in the ready-to-use solution is from about 0.01 to about 8.0 w/w %of the solution. Typically, the ready-to-use solution contains from 0.1to 5.0 w/w % of the carboxylic acid, which is dependent on the storagestability as well as the application of the solution.

Examples of mineral acids include, but are not limited to, phosphoricacid, sulfuric acid and hydrochloric acid. The amount of mineral acid inthe concentrate is from about 0.1 to about 10 w/w % of the formulation.Preferably, the concentrate contains from 0.2 to 5 w/w % of the mineralor non-carboxylic, organic acid. The amount of mineral acid in theready-to-use solution is from about 0.01 to about 0.5% of the solution.Preferably, the ready-to-use solution contains from 0.01 to 0.3 w/w % ofthe mineral acid.

To alter the pH values, buffers or other pH adjusting agents may beadded to the formulations. The amounts of the acids described above maybe increased to decrease the pH. To increase the pH, salts of the acidsdescribed herein may be used or, basic compounds or solutions, such assodium hydroxide and potassium hydroxide or the alkali metal andammonium salts of phosphoric acid, citric acid, and sulfuric acid. ThepH of the concentrate is from about 0.5 to about 5, and more preferablyfrom 1 to 3. The pH of the ready-to-use solution is from about 1.0 toabout 4.5, and more preferably from 2 to 3.

The concentrate and ready-to-use solution may also contain a biocidalquaternary ammonium salt to increase the biocidal activity of theformulation. Examples of quaternary ammonium salts to be used include,but are not limited to, didecyl dimethyl ammonium chloride (“DDAC”) andalkyl dimethyl benzyl ammonium chlorides. The quaternary ammonium saltmay be present in the concentrate in an amount from about 0.1 to about10 weight percent, and in the ready-to-use solution in an amount fromabout 0.01 to about 2.0 weight percent.

In another embodiment, the concentrate and ready-to-use solution of themay further include a stabilizer to deactivate impurities that can causehydrogen peroxide decomposition. The stabilizer may be added to preventthe components from decomposing on the shelf prematurely during storageof the formulations. Known stabilizers for use in stabilizing acidichydrogen peroxide solutions include organic and inorganic sequesteringagents, i.e., stannates and phosphates, and combinations of organiccompounds, organometallic salts and metal chelators with or withoutstannates and phosphates. In one embodiment, the stabilizer may bephosphoric acid, if not already present in the composition, a derivativeof phosphoric acid, 1-hydroxyethylidenediphosphonic acid (HEDP), phyticacid, aminophosphate, phosphonate and sodium glutamate, NaH₂PO₄,Na₅P₃O₁₀, organophosphonic acid, amino-phosphonate, silver dihydrogencitrate, diphosphonic acid, ethylenediaminetetraacetic acid (EDTA),N-(hydroxyethyl)-ethylenediaminetriacetic acid (HEDTA), tri(methylenephosphoric acid), diethylenetriaminepenta(methylene phosphoric acid),2-hydroxy ethylimino bis(ethylene phosphoric acid), citric acid,dipicolinic acid, ethylenediamine-N,N′-disuccinic acid,methylglycinediacetic acid and their alkaline salts thereof,nitriotriacetic acid (NTA), 2-hydroxyethylimino-diacetic acid (HEIDA),and salts thereof, cyclohexane-1,2-diaminotetrakismethylene phosphonicacid or water-sol, diethylenetriamine penta(methylene phosphonic acid),colloidal stannate, diethylenetriamine pentaacetic acid (DTPA), citratesalts, gallate salts, malate salts, malonate salts, oxaloacetate salts,oxalate salts, pyruvate salts, succinate salts,2-hydroxypyridine-1-oxide (2-HPNO), hyroxyethylidene diphosphonic acid(HEDP) zinc salt, triethanol amine phosphate or mixtures thereof. Thehydrogen peroxide stabilizer can be a single component or a mixture ofthe derivatives of phosphoric acid and the chelators described above.The amount of the optional stabilizer in the concentrate can be fromabout 0.01% to about 5 w/w %, preferably from 0.05% to 2 w/w %, and morepreferably from 0.1% to 1.0 w/w %.

In one another embodiment, the concentrate and ready-to-use solution ofthe may further include a zwitterionic surfactant, an ionic surfactant,or both. An example of an ionic surfactant includes sodium dodecylsulfate. The amount of the zwitterionic surfactant and the ionicsurfactant can each range in 0.5 to 5 w/w % of the total composition.

Other additives may be also added to the antimicrobial composition ofthe present disclosure to provide the composition with suitableproperties for end use applications. Typical examples include corrosioninhibitors, emulsifiers, fragrances, dyes, preservatives, antifoamagents, thickening agents, hydrotrope agents, and mixtures thereof.

In one embodiment, for instance, the concentrate and ready-to usecompositions may include a corrosion inhibitor. Corrosion inhibitorsthat may be used include, but are not limited to, borates, phosphates,polyphosphates, sodium benzoate, sodium gluconate, sodium silicate,sodium molybdate, sodium bisulfate, benzotriazole or mixtures thereof.When present, the corrosion inhibitor can be contained in thecomposition in an amount from about 0.001% to about 10% by weight, suchas from about 0.01% to about 1% by weight.

In another embodiment, according to present invention, the concentrateformulation is a solid formulation which can be either a powder or intablet form. In such embodiments, the formulation comprises at least onehydrogen peroxide releasing component chosen from sodium percarbonate,sodium perborate monohydrate, and sodium perborate tetrahydrate,hydrogen peroxide urea adduct, preferably sodium percarbonate, at leastone organic acid selected from citric acid, succinic acid and benzoicacid, at least one solid nonionic surfactant, in combination with otheringredients such as stabilizers, corrosion inhibitors, dyes, fragrancesand preservatives depending on application.

One advantage of a solid formulation is that some hydrogen peroxidebased solutions may be unstable with the hydrogen peroxide concentrationdiminishing greatly in time due to catalytic decomposition. This may beresolved by a producing a dry powdered formulation with solidingredients such as toluenesulfonic acid, sodium percarbonate, solidnonionic surfactant and solid organic acid such as citric acid, succinicacid, adipic acid, and other adjuvant materials in the mixture evenwithout the addition of phosphorus-based stabilizers.

The concentrate formulation and the powder form can be dissolved inwater by an end-user to produce a ready-to-use solution directly forvarious applications. For example, disinfectant tablets can be producedin the different size and shapes using the powdered formulation. Theend-user can disinfect via a simmer or feeder. The resulting tabletsprovide practical, convenient and benefits for the end-users,particularly, to disinfect and clean large veterinary and poultryfacility and food manufacture, equipment, instrument, and large floorareas. In another embodiment, the concentrate can include all the abovedescribed components ingredients but for aqueous hydrogen peroxide andwater. The end-user can then add aqueous hydrogen peroxide and waterjust prior to use.

In accordance with the invention, an end-user can disinfect a surface ofharmful microorganisms by contacting the surface with the prepareddisinfecting compositions as noted above. The surface is contacted foran amount of time effective to kill a majority of the microbes locatedon the surface. A “majority” in this context mean a kill rate of atleast 50% within one (1) minute of contact. In a more preferredembodiment, the kill rate is a 5 Log₁₀ reduction within one (1) minuteof contact. Microorganisms intended to be killed include Gram positivebacteria, Gram negative bacteria, viruses, fungi, mildew, mold orcombinations thereof. Specific examples of microorganisms to be killedare Staphylococcus, Pseudomonas, hepatitis, rotavirus, rhinovirus,tuberculosis or combinations thereof.

The hydrogen peroxide may optionally be provided to the end-userseparate from the sulfonic acid and nonionic surfactant. That is thecomposition may be provided as a two-part formulation to the end-user inseparate containers and the end-user mixes the two parts together priorto use. In addition, the end-user may also add additional water to theformulation to adjust the formulation to the ready-to-use compositions.Additional components are typically provided to the first partcontaining the sulfonic acid and nonionic surfactant to prevent possiblecatalytic decomposition of the hydrogen peroxide during storage.

The disinfectant compositions of the present invention can be used innumerous and diverse applications. In one embodiment, for instance, thecompositions of the invention may be used to sanitize or disinfect hard,non-porous surfaces. For example, the composition of the invention iswell suited for disinfecting or sanitizing flooring materials,countertops, ceramic surfaces, metal surfaces, glass surfaces, stonesurfaces, and the like. The compositions can be used to clean thesurfaces, destroy microorganisms on the surface and/or prevent growth ofmicroorganisms on the surface. Likewise, the compositions can be used inthe food service industry to disinfect and sanitize food processingequipment and other food processing surfaces or to wash produce, such asvegetables. The compositions can also be used in the healthcare industryto disinfect surfaces, facility, equipment and hospital instruments andequipment, and/or disinfect utensils. The compositions can be used in aconcentrated or diluted form depending upon the application.

The following non-limiting examples illustrate the advantageous use ofthe hydrogen peroxide compositions of the present invention that may beused in wipe in any suitable application where disinfecting, sanitizing,and cleaning and/or bleaching are desired.

EXAMPLES Example 1

Several formulations were screened for antimicrobial activity againstusing Staphylococcus aureus (“Sa”) and Pseudomonas aeruginosa (“Pa”)using a microtiter plate method. Challenge solutions were prepared foreach of the concentrations to be evaluated. The test formulation attwice the desired concentrations were prepared in hard water, and addedto a microtiter plate. Inoculum was prepared to 1×10⁸ CFU, and 100 uLwas added to each challenge solution in the microtiter plate.Staphylococcus aureus (“Sa”) ATCC 6538 and Pseudomonas aeruginosa (“Pa”)ATCC 15442 were tested.

After the appropriate contact time (either 1 min. or 30 sec.), thesamples were neutralized by removing 20 uL of the inoculated-challengesolution and adding 180 uL of neutralizer. Serial dilutions of theneutralized, inoculated-challenge solutions were made in growth media todetermine log growth. A control was made with inoculated hard water onlyto determine maximum growth. Plates were incubated at 35° C. for 2 daysbefore reading results. Each solution was tested in triplicate. Logreduction was calculated using the growth of the control as a baseline.The results are shown in Table 1 below.

TABLE 1 # Log₁₀ # Log₁₀ # Log₁₀ #Log₁₀ Reduction Reduction Reduction,Reduction H₂O₂ in 1 min contact 1 min contact 1 min contact 1 mincontact Sample Sample 0.5% H₂O₂ 0.25% H₂O₂ 0.1% H₂O₂ 3% PA IDComposition (%) Pa Sa Pa Sa Pa Sa Pa Sa 1-1* H₂O₂ 0.5 0 0 1-2* 3.0% PA0.0 1.14 0.35 1-3* 3.0% PA + 5.0 5.7 0.28 5% H₂O₂ 1-4* 5.1% PA + 5.06.39 2.93 6.64 0.36 5.0% Stepanate ® DA-6 + 0.2% HEDP + 5.0% H₂O₂ 1-54.0% TSA + 5.2 4.95 4.44 6.36 6.08 1.73 0.26 3.0% Stepantex ® DA-6 +0.4% HEDP + 0.4% PA + 5.2% H₂O₂ 1-6 7.0% TSA + 5.0 5.37 5.35 6.30 0.843.0% Stepanate ® DA-6 + 0.8% PA + 5.0% H₂O₂ 1-7 7.0% TSA + 5.0 6.39 6.166.64 0.71 3.0% Stepanate ® DA-6 + 3.0% PA + 5.0% H₂O₂ *comparativesample; TSA—toluenesulfonic acid; PA—phosphoric acid - hydrogen peroxidestabilizer; HEDP—1-hydroxyethane 1,1-diphosphonic acid - hydrogenperoxide stabilizer; and Stepanate ® DA-6 - a decyl alcohol ethoxylatedPOE-6 - non-ionic surfactant.

As shown in Table 1, comparative sample 1-1 containing hydrogen peroxidealone showed no antimicrobial efficacy against Pa and Sa. Comparativesample 1-2 containing phosphoric acid alone showed poor antimicrobialefficacy against Pa and Sa. Comparative sample 1-3, a combination ofphosphoric acid and hydrogen peroxide, did provide a good activityagainst Pa (with a 5.7 Log₁₀ reduction) but not against Sa (with a 0.28Log₁₀ Reduction) at a diluted concentration of 0.5% peroxide. However,comparative sample 1-3 at peroxide concentration of 0.25% and 0.1% wasnot effective against either Pa or Sa. Comparative sample 1-4, acombination of a nonionic surfactant, Stepanatex® DA-6 and the mixtureof hydrogen peroxide and phosphoric acid, also showed improved efficacyagainst both Pa and Sa. At 0.25% peroxide, sample 1-4 exhibited a 6.39Log₁₀ reduction against Pa. At 0.1% peroxide, sample 1-4 exhibited a6.64 Log₁₀ reduction against Pa. TSA and Stepanatex® DA-6, alone or incombination, were not tested since the compounds are well known not tohave anti-microbial activity. Also shown in Table 1 is that the additionof TSA to the combination of peroxide, PA and Stepanatex® DA-6 furtherenhanced the efficacy of the solution against both Pa and Sa. The datashow that the addition of TSA significantly improved the kill rateagainst Sa.

Example 2

Based on the screening results in example 1, additional formulationscontaining either toluene sulfonic acid (“TSA”) or methane sulfonic acid(“MSA”) were evaluated for biocidal activity of using the OECDquantitative method for evaluating bacterial activity on hard non-poroussurfaces. See 30 Oct. 2012 Draft—OECD Quantitative Methods forEvaluating the Activity of Microbicides Used on Hard Non-PorousSurfaces. The following raw materials were obtained from Aldrich-Sigma:50% by weight hydrogen peroxide; 99% by weight citric acid (“CA”); 85%by weight phosphoric acid; 99% by weight glutaric acid (“GA”); 60% byweight 1-hydroxyethane 1,1-diphosphonic acid (“HEDP”); 98% by weighttoluensulfonic acid monohydrate (“TSA”); 95% by weight sodium stannatetrihydrate; 99% by weight dipicolinic acid (“DPA”); and 35% by weightS,S-ethylenediamine-N,N′-disuccinic acid trisodium salt (“EDDS”).Stepantex® DA-6, a decyl alcohol ethoxylated POE-6, was obtained fromStepan Company.

Test samples were prepared and evaluated, in which the results are shownin Table 2. Not listed in Table 2 are test samples containing hydrogenperoxide alone that were evaluated at concentrations of 1% by weight.

As in example 1, the efficacy of the hydrogen peroxide solutions wereevaluated against Staphylococcus aureus (“Sa”) ATCC 6538 and Pseudomonasaeruginosa (“Pa”) ATCC 15442. The test samples were diluted in OECD hardwater prepared according to the test methodology to achieveapproximately 375 ppm sample+5%/−10% (338-394 ppm) to ascertain thecalculated level of hydrogen peroxide based on the amount of hydrogenperoxide used to prepare the formulations. A pass criterion wasconsidered a microbial reduction being a Log₁₀≧4.

TABLE 2 # Log Reduc., # Log Reduc., 1 min contact 3 min contact Sample1.0% H₂O₂ 0.5% H₂O₂ ID Composition Pa Sa Pa Sa 2-1 5% H₂O₂ + 8% TSA + 4%Stepantex ® DA-6 + 0.2% >5.0 <4.0 5.6 5.0 HEDP + 3.5% PA (pH: 1.6) 2-25% H₂O₂ + 7% TSA + 3% Stepantex ® DA-6 + 3% 6.0 6.1 GA + 3% PA + 0.2%HEDP (pH: 1.6) 2-3 5% H₂O₂ + 10% TSA + 2% Stepantex ® DA-6 + 2% 6.4 6.1PA (pH: 1.2) 2-4 5.0% H₂O₂ + 8% MSA + 3% Stepanatex ® DA-6 + >5.0 <4.06.0 4.4 0.1% EDDS (pH ~1.25) 2-5 5.0% H₂O₂ + 1.5% CA + 8% MSA + 3%Stepanatex ® >5.0 <4.0 5.5 4.9 DA-6 + 0.20% HEDP sodium salt (pH: 1.75)2-6 5.0% H₂O₂ + 1.5% CA + 8% TSA + 3% Stepanatex ® >5.0 <4.0 5.5 5.7DA-6 + 0.20% HEDP sodium salt (pH: 1.78) 2-7 5.0% H₂O₂ + 1.5% CA + 8%TSA + 1.5% Stepanatex ® >5.0 <4.0 5.5 5.2 DA-6 + 0.20% EDDS (pH: 1.78)2-8 5% H₂O₂ + 3% CA + 7% TSA + 3% Stepantex ® DA-6 + 6.4 5.5 2% PA (pH:1.3) 2-9 1.0% H₂O₂ + 2% CA+ 1.6% TSA + 0.8% Stepanate ® 5.28 <3.9 DA-6 +0.4% PA (pH: 1.68) 2-10 1.0% H₂O₂ + 1.6% TSA + 4.5% CA + 0.4%Stepanatex ® 6.0 6.0 DA-6 + 0.1% EDDS (pH ~1.76) 2-11 1.0% H₂O₂ + 1.6%TSA + 4% CA + 0.4% Stepanate ® 6.0 4.4 DA-6 + 0.1% EDDS (pH ~1.74)TSA—toluenesulfonic acid; MSA—methanesulfonic acid; PA—phosphoric acid;HEDP—edidronic acid; GA—glutaric acid; CA—citric acid; Stepantex ®DA-6—decyl alcohol ethoxylated POE-6;EDDS—S,S-ethylenediamine-N,N′-disuccinic acid trisodium salt

As shown in Table 2, samples containing MSA exhibited anti-microbialefficacy comparable to samples containing TSA. Samples 2-1 to 2-8 passedwith 4 Log₁₀ reductions within 3 minutes against both Pa and Sa. Samples2-10 and 2-11 additionally containing organic acid, GA and CA, passedwith 4 Log₁₀ reductions within a much shorter contact time of 1 minuteagainst both Pa and Sa.

Example 3

Samples 2-8 and 2-11 were also tested at their 0.5% H₂O₂ level againstStaphylococcus aureus ATCC 6538 (“Sa”) and Pseudomonas aeruginosa ATCC15442 (“Pa”) using the AOAC Germicidal Spray Test method in Organic soilload: 5% Fetal Bovine Serum (FBS). The results are shown in Table 3below. Both samples passed Germicidal Spray test with <1/60Positive/Total Carriers Exposed at 0.5% H₂O₂ level within 1 min contacttime against both Pa and Sa.

TABLE 3 Log10 Average Positive/Total Dried Carrier Carriers ExposedControl Sample# Contact time Pa Sa Pa Sa 2-8 1 min 0/60 1/60 6.69 6.422-11 1 min 0/60 1/60 6.61 6.42

While the invention has been described above with examples to specificembodiments thereof, it is impossible to cover all scope the invention.Many changes, modification and variations with the process andcompositions of the invention will thereof be obvious to those skilledin the art, all of which are within the spirit and scope of thisinvention without desertion of the inventive concept disclosed herein.

We claim:
 1. A hydrogen peroxide, disinfectant concentrate comprising: ahydrogen peroxide source, a non-surfactant organic sulfonic acid or saltthereof, and a non-ionic surfactant.
 2. The hydrogen peroxidedisinfectant concentrate of claim 1, wherein the non-surfactant organicsulfonic acid is selected from the group consisting of a C₁-C₅alkylsulfonic acid, a sulfonated C₁-C₅ carboxylic acid, a substituted orunsubstituted aromatic sulfonic acid, mono-alkylphenylsulfonic acid, adi-alkylphenylsulfonic acid, and mixtures thereof, wherein thesubstituted aromatic sulfonic acid is substituted with at least oneC₁-C₃ alkyl group.
 3. The hydrogen peroxide, disinfectant concentrate ofclaim 2, wherein the C₁-C₅ alkylsulfonic acid is methanesulfonic acid.4. The hydrogen peroxide, disinfectant concentrate of claim 2, whereinthe unsubstituted aromatic sulfonic acid is benzene sulfonic acid. 5.The hydrogen peroxide, disinfectant concentrate of claim 2, wherein thesubstituted aromatic sulfonic acid is toluene sulfonic acid,xylenesulfonic acid, ethylbenzene sulfonic acid or mixtures thereof. 6.The hydrogen peroxide, disinfectant concentrate of claim 1, wherein thesalt is an alkali metal salt, an alkaline earth metal salt or anammonium salt.
 7. The hydrogen peroxide, disinfectant concentrate ofclaim 1, further comprising of an optional acid other than thenon-surfactant organic sulfonic acid.
 8. The hydrogen peroxide,disinfectant concentrate of claim 7, wherein the optional acid isphosphoric acid, etidronic acid, or mixtures thereof.
 9. The hydrogenperoxide, disinfectant concentrate of claim 7, wherein the optionaladded is a carboxylic acid selected from the group consisting of a C₁ toC₈ mono-, di-, or tricarboxylic acid, a C₁ to C₈ hydroxyl carboxylicacid, a substituted or unsubstituted aromatic carboxylic acid, andmixtures thereof.
 10. The hydrogen peroxide, disinfectant concentrate ofclaim 7, wherein the optional acid is a mineral acid.
 11. The hydrogenperoxide, disinfectant concentrate of claim 10, wherein the nonionicsurfactant is a C₈ to C₁₄ alkylated polyethylene glycol, C₈ to C₁₄alkylated polypropylene glycol, polyoxyethylene glycol alkylphenolethers and gluco side alkyl ethers, or mixtures thereof.
 12. Thehydrogen peroxide, disinfectant concentrate of claim 1, wherein thehydrogen peroxide source is from about 2 to about 8 weight percent ofthe total concentrate.
 13. The hydrogen peroxide, disinfectantconcentrate of claim 1, wherein the concentration of the organicsulfonic acid is from about 2 to about 15 weight percent of the totalconcentrate.
 14. The hydrogen peroxide, disinfectant concentrate ofclaim 9, wherein the carboxylic acid is from about 0.2 to about 10weight percent of the total concentrate.
 15. The hydrogen peroxide,disinfectant concentrate of claim 8, wherein the mineral acid is fromabout 0.2 to about 10 weight percent of the total concentrate.
 16. Thehydrogen peroxide, disinfectant concentrate of claim 1, wherein thenonionic surfactant is from about 0.5 to about 8 weight percent of thetotal concentrate.
 17. The hydrogen peroxide, disinfectant concentrateof claim 1, further comprising of a hydrogen peroxide stabilizer and ametal corrosion inhibitor each in a concentration of about 0.05 to about0.5 weight percent of the total concentrate.
 18. The hydrogen peroxide,disinfectant concentrate of claim 1, wherein the concentrate is a solidformulation in the form of a powder or tablet.
 19. The hydrogenperoxide, disinfectant concentrate of claim 1, wherein the hydrogenperoxide source is hydrogen peroxide solution, sodium percarbonate,potassium percarbonate, sodium and potassium perborate, hydrogenperoxide urea, hydrated forms thereof, or mixtures thereof.
 20. Aready-to-use hydrogen peroxide, disinfectant solution comprising: abiocidal amount of hydrogen peroxide, a non-surfactant organic sulfonicacid or salt thereof, a non-ionic surfactant, and water.
 21. Theready-to-use hydrogen peroxide, disinfectant solution of claim 20,wherein the biocidal amount of hydrogen peroxide is from about 0.05 toabout 5.0 weight percent of the total solution.
 22. The ready-to-usehydrogen peroxide, disinfectant solution of claim 20, wherein thenon-surfactant organic sulfonic acid is from about 0.05 to about 5.0weight percent of the total solution.
 23. The ready-to-use hydrogenperoxide, disinfectant solution of claim 20, further comprising acarboxylic acid from about 0.05 to about 6.0 weight percent of the totalsolution.
 24. The ready-to-use hydrogen peroxide, disinfectant solutionof claim 20, wherein the nonionic surfactant is from about 0.05 to about3.0 weight percent of the total solution.
 25. The ready-to-use hydrogenperoxide, disinfectant solution of claim 20, further comprising amineral acid from about 0.05 to about 5 weight percent of the totalsolution.
 26. The ready-to-use hydrogen peroxide, disinfectant solutionof claim 20, wherein the solution has a pH of from about 1.0 to about4.0.
 27. The ready-to-use hydrogen peroxide, disinfectant solution ofclaim 20, wherein the non-surfactant organic sulfonic acid is selectedfrom the group consisting of a C₁-C₅ alkylsulfonic acid, a sulfonatedC₁-C₅ carboxylic acid, a substituted or unsubstituted aromatic sulfonicacid, mono-alkylphenylsulfonic acid, a di-alkylphenylsulfonic acid, andmixtures thereof, wherein the substituted aromatic sulfonic acid issubstituted with at least one C₁-C₃ alkyl group.
 28. The ready-to-usehydrogen peroxide, disinfectant solution of claim 27, wherein the C₁-C₅alkylsulfonic acid is methanesulfonic acid.
 29. The ready-to-usehydrogen peroxide, disinfectant solution of claim 27, wherein theunsubstituted aromatic sulfonic acid is benzene sulfonic acid.
 30. Theready-to-use hydrogen peroxide, disinfectant solution of claim 27,wherein the substituted aromatic sulfonic acid is toluene sulfonic acid,xylenesulfonic acid, ethylbenzene sulfonic acid or mixtures thereof. 31.The ready-to-use hydrogen peroxide, disinfectant solution of claim 20,wherein the salt is an alkali metal salt, an alkaline earth metal saltor an ammonium salt.
 32. The hydrogen peroxide disinfectant concentrateof claim 1, further comprising of biocidal quaternary ammonium salt inan amount from about 0.1 to about 10 weight percent of the totalconcentrate.
 33. The ready-to-use hydrogen peroxide, disinfectantsolution of claim 20, comprising of biocidal quaternary ammonium salt inan amount from about 0.1 to about 5 weight percent of the solution. 34.A method of disinfecting a surface of microorganisms, the methodcomprising: contacting said surface with a disinfecting compositioncomprising of (i) a biocidal amount of hydrogen peroxide, (ii) anon-surfactant organic sulfonic acid or salt thereof, (iii) a non-ionicsurfactant, and (iv) water; wherein said surface is contacted for anamount of time effective to kill a majority of the microbes located onthe surface.
 35. The method of claim 34, wherein the microorganisms areGram positive bacteria, Gram negative bacteria, viruses, fungi, mildew,mold or combinations thereof.
 36. The method of claim 34, wherein themicroorganisms are Staphylococcus, Pseudomonas, hepatitis, rotavirus,rhinovirus, tuberculosis or combinations thereof.
 37. The method ofclaim 34, wherein the surface is a floor, a wall, a countertop, anappliance, or a fixture.
 38. The hydrogen peroxide, disinfectantconcentrate of claim 1, further comprising about 0.5 to about 5 weightpercent of a zwitterionic surfactant.
 39. The ready-to-use hydrogenperoxide, disinfectant solution of claim 20, further comprising about0.5 to about 5 weight percent of a zwitterionic surfactant.
 40. Atwo-part disinfectant, comprising: a first container including anon-surfactant organic sulfonic acid or salt thereof, and a non-ionicsurfactant; and a second container including a biocidal amount ofhydrogen peroxide, and water.
 41. The two-part disinfectant of claim 38,wherein additional components are included only in the first container.42. The ready-to-use hydrogen peroxide, disinfectant solution of claim20, further comprising a water-miscible organic solvent selected fromthe group consisting of ethanol, propanol, benzyl alcohol,phenoxyethanol, isopropanol, diethylene glycol propyl ether, ethyleneglycol monomethyl ether, ethylene glycol monoethyl ether, ethyleneglycol monopropyl ether, ethylene glycol monoisopropyl ether, ethyleneglycol monobutyl ether, diethylene glycol monomethyl ether, diethyleneglycol monobutyl ether, diethylene glycol monoethyl ether, diethyleneglycol mono-n-butyl ether, ethylene glycol dimethyl ether, ethyleneglycol diethyl ether, ethylene glycol dibutyl ether, propylene glycoln-butyl ether, tripropylene glycol methyl ether, dipropylene glycolmethyl ether, dipropylene glycol butyl ether and combinations thereof.43. The hydrogen peroxide, disinfectant concentrate of claim 1, furthercomprising about 0.5 to about 5 weight percent of an ionic surfactant.44. The ready-to-use hydrogen peroxide, disinfectant solution of claim20, further comprising about 0.5 to about 5 weight percent of an ionicsurfactant.